Mefenamic Acid: Uses, Risks, and Alternatives for Pain and Inflammation

When you reach for mefenamic acid, a nonsteroidal anti-inflammatory drug used to treat mild to moderate pain, especially menstrual cramps. Also known as Ponstel, it works by blocking chemicals in your body that cause pain and swelling. But here’s the thing — it’s not just another pill. Like other NSAIDs, it can quietly hurt your kidneys, strain your liver, and even raise your risk of heart problems if you take it long-term or in high doses.

Many people use mefenamic acid for period pain because it works fast and doesn’t make them drowsy like some other options. But if you’re taking it every month, or for back pain, arthritis, or headaches over weeks or months, you’re putting stress on organs that don’t always show warning signs until it’s too late. Studies show NSAIDs like mefenamic acid are linked to acute kidney injury, especially in people who are dehydrated, older, or already have high blood pressure. Liver enzyme spikes? They happen. Heart risks? They’re real — especially if you have existing cardiovascular issues.

It’s not just about mefenamic acid. It’s part of a bigger group — the NSAIDs — that includes ibuprofen, naproxen, and diclofenac. Each has its own profile, but they all share the same hidden dangers. If you’re using one for chronic pain, you should know how it compares to safer alternatives. Topical gels, acetaminophen, or even physical therapy might give you relief without the internal toll. And if you’re taking it for menstrual cramps, there are hormonal and non-hormonal options that target the root cause instead of just masking the pain.

What you’ll find below is a collection of real, practical guides that connect directly to your experience with mefenamic acid. You’ll see how it stacks up against other pain meds, what signs of organ damage to watch for, and how to switch to safer options without losing control of your symptoms. These aren’t theoretical — they’re based on what people actually face when they take these drugs day after day. Whether you’re worried about your kidneys, tired of stomach upset, or just want to know if there’s a better way — the answers are here.